The chief action of Uranium nitr. is upon the kidneys where it causes a degeneration, with albuminuria or glycosuria. It increases the total quantity and specific gravity of the urine and produces acidity, with mucus discharges and incontinence. Its chief therapeutic application has been in the treatment of diabetes (both mellitus and insipidus) and in Bright s disease. With diabetes, the small blood vessels in the body are injured. When the blood vessels in the kidneys are injured, your kidneys cannot clean the blood properly. The body will retain more water and salt than it should, which can result in weight gain and ankle swelling. You may have protein in your urine. Use under medical supervision.